Persch Tablets Specification

• Requires Prescription: Yes
• Generics: Risperidone
• Used For: Schizophrenia

Mechanism of Action The precise mechanism of action of risperidone in schizophrenia is not fully understood. However, its therapeutic effects are thought to be due to its antagonism at dopamine Type 2 (D2) and serotonin Type 2 (5HT2) receptors. The clinical efficacy of risperidone is attributed to the combined activity of risperidone and its primary metabolite, 9-hydroxyrisperidone (paliperidone). The drug’s effects at other receptors may explain additional clinical outcomes.

Persch Tablets Usage and Safety

• Dosage: Risperidone
• Side Effects:
  • Increased mortality in elderly patients with dementia-related psychosis
  • Cerebrovascular adverse events, including stroke, in elderly patients with dementia-related psychosis
  • Neuroleptic malignant syndrome (NMS)
  • Tardive dyskinesia
  • Metabolic changes (hyperglycemia, diabetes mellitus, dyslipidemia, and weight gain)
  • Hyperprolactinemia
  • Orthostatic hypotension
  • Falls
  • Leukopenia, neutropenia, and agranulocytosis
  • Potential for cognitive and motor impairment
  • Seizures
  • Dysphagia
  • Priapism
  • Disruption of body temperature regulation
  • Patients with phenylketonuria

Drug Interactions Risperidone may interact with various medications, including fluoxetine, paroxetine, carbamazepine, ranitidine, cimetidine, erythromycin, amitriptyline, levodopa, ketoconazole, verapamil, furosemide, paliperidone, dopamine agonists, rifampicin, and anticholinergics.

Indication Risperidone is indicated for the treatment of schizophrenia.

Contraindications Risperidone is contraindicated in patients with known hypersensitivity to risperidone, paliperidone, or any of the excipients in the formulation. Hypersensitivity reactions, including anaphylactic reactions and angioedema, have been reported.

Persch Tablets Precautions Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.

Persch Tablets Warnings

• Warning 1: Neuroleptic Malignant Syndrome (NMS), a potentially fatal condition, has been reported with antipsychotic drugs.
• Warning 2: Tardive dyskinesia, a potentially irreversible condition characterized by involuntary, dyskinetic movements, may develop with antipsychotic treatment.
• Warning 3: Atypical antipsychotics, including risperidone, have been associated with metabolic changes such as hyperglycemia, dyslipidemia, and weight gain, which may increase cardiovascular/cerebrovascular risk. Each drug in this class has its own specific risk profile.

Persch Tablets Additional Information

• Pregnancy Category: Always consult your physician before using any medicine.
• Storage: Store this medicine at room temperature, away from direct light and heat.