Panadol Extend Tablets 665Mg

Panadol Extend Specifications:

• Requires Prescription: No
• Generics: Paracetamol
• Used For: Pain & Fever

How it Works: Paracetamol exerts a central analgesic effect by activating serotonergic pathways. Its primary action may involve inhibiting prostaglandin synthesis or influencing cannabinoid receptors through active metabolites.

Panadol Extend Usage and Safety:

• Dosage: Paracetamol
• Common Side Effects: Thrombocytopenia, cutaneous hypersensitivity reactions (e.g., skin rashes, angioedema), bronchospasm in aspirin-sensitive patients, hepatic dysfunction.
• Drug Interactions: Prolonged daily use of paracetamol may enhance the anticoagulant effect of warfarin, increasing the risk of bleeding.

Indication: Panadol Extend provides fast relief for:

• Headache
• Migraine pain
• Joint pain associated with Osteoarthritis
• Muscle ache
• Toothache
• Period pain
• Fever

When Not to Use: Contraindicated in patients with a history of hypersensitivity to paracetamol or its excipients.

Panadol Extend Precautions:

• Contains paracetamol; avoid concurrent use with other paracetamol-containing products to prevent overdose.

Panadol Extend Warnings:

1. Patients with underlying liver disease are at increased risk of paracetamol-related liver damage. Medical advice is essential for those with liver or kidney impairment.
2. Hepatic dysfunction/failure may occur in individuals with depleted glutathione levels, such as those who are malnourished, anorexic, have a low BMI, or are chronic heavy alcohol users.
3. Use caution in patients with glutathione-depleted states (e.g., sepsis) as paracetamol may increase the risk of metabolic acidosis.

Additional Information:

• Pregnancy Category: Consult your physician before use.
• Storage: Store at room temperature, protected from light and heat.